Dr. Tavtigian is a professor in the Department of Oncological Sciences at the University of Utah and a co-leader of the Huntsman Cancer Institute’s Cancer Control and Population Sciences Program.
Previously, he held a position at Myriad Genetics before taking a position with the International Agency for Research on Cancer (IARC, Lyon, France), which is the cancer research arm of the World Health Organization. There, he contributed to development of methods for clinical classification of Variants of Uncertain Significance (VUS) in cancer susceptibility genes and development of guidelines for classification of VUS in cancer susceptibility genes.
In 2009, Dr. Tavtigian returned to the University of Utah Department of Oncological Sciences. Here, continuing work started towards the end of his time at IARC, he has calibrated computational methods for evaluating VUS in cancer susceptibility genes. Using these methods, he has also elucidated the role of rare missense substitutions in moderate-risk cancer susceptibility genes. He has also extended quantitative Bayesian methods of VUS classification to cover all high-risk susceptibility genes for simple Mendelian diseases.